WHO issues unprecedented global guidelines to combat infertility

The World Health Organisation (WHO) on Friday (November 28, 2025) published for the first time directives to improve the prevention, detection and treatment of infertility, which affects millions across the globe.

“One in six people worldwide experience infertility during their lifetime,” said Pascale Allotey, the global health body’s head of sexual and reproductive health.

“The condition affects individuals and couples across all regions yet access to safe and affordable care remains highly inequitable”, said Ms. Allotey.

The new guide would provide a “unified, evidence-based foundation” to ensure care is safe, effective and accessible for all, she added.

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According to the WHO, infertility is a condition of the male and female reproductive system, defined as the inability to achieve pregnancy after 12 months or more of regular unprotected sexual relations.

The situation can lead to major distress, stigmatisation and financial difficulties. In several countries, most of the cost of infertility tests and treatment is borne by patients, which often leads to “catastrophic financial expenditures”.

“In some settings, even a single round of In Vitro Fertilisation (IVF) can cost double the average annual household income,” the WHO noted.

The guide sets out 40 recommendations and calls for the integration of fertility in national health funding, services and strategies.

It also wants to see steps for effective clinical management, in both diagnosis and treatment.

For example, the WHO calls for male diagnoses, which are often under-investigated, suggesting a range of approaches, starting with advice before moving to active treatment. It also advises increased investment in prevention.

Health professionals need to address the main risk factors for infertility, which include untreated sexually transmitted infections and smoking, the global health body noted.