Nagaland University identifies natural compound with potential for diabetic wounds treatment

admin — Tue, 21 Oct 2025 12:27:00 +0000

The key implications of this discovery include reducing the risk of amputation and accelerating recovery in diabetic foot ulcers and providing an affordable, natural oral therapy, improving accessibility for patients in rural and resource-limited settings |Image used for representational purpose only
| Photo Credit: Getty Images

Nagaland University researchers have identified a naturally occurring plant compound called “Sinapic acid” as a powerful therapeutic agent capable of significantly accelerating wound healing in diabetic conditions, according to officials.

The discovery marks a major advancement that could result in safe, natural and effective treatments for diabetic wound management, they said.

According to Panav Kumar Prabhakar, Head, Department of Biotechnology, Nagaland University, this is the first study globally to demonstrate that Sinapic acid, when administered orally, can accelerate diabetic wound healing in preclinical models. The research established that the compound works by activating the SIRT1 pathway, which plays a crucial role in tissue repair, angiogenesis and inflammation control.

The findings have been published in Nature Scientific Reports, a peer-reviewed, open-access journal from Nature Portfolio (Springer Nature).

“This discovery not only highlights the strength of our scientific community but also reflects our commitment to addressing pressing health challenges through innovation rooted in nature. I congratulate the research team for their dedication and contribution towards improving healthcare solutions,” said Jagadish K Patnaik, Vice Chancellor, Nagaland University.

Prabhakar explained that diabetes mellitus remains one of the world’s most pressing chronic diseases, affecting hundreds of millions globally.

“Among its serious complications is delayed wound healing, often resulting in diabetic foot ulcers, infection and in severe cases, amputation. Existing synthetic drugs have shown limited efficacy and often cause undesirable side effects,” he said.

“We set out seeking a safe, plant-based alternative — exploring how Sinapic acid, a naturally occurring antioxidant found in various edible plants, could accelerate tissue repair, reduce inflammation, and promote new blood vessel formation in diabetic wounds,” he added.

The researchers explained that we found that a lower dose (20 mg/kg) was more effective than a higher one (40 mg/kg), a phenomenon known as “Inverted Dose-Response”.

“This result not only optimises dosage strategy but also has significant clinical implications for future drug development. The key implications of this discovery include reducing the risk of amputation and accelerating recovery in diabetic foot ulcers and providing an affordable, natural oral therapy, improving accessibility for patients in rural and resource-limited settings,” he said.

Published – October 21, 2025 05:57 pm IST

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Scientists Discover Potential Baldness Treatment During Wound Healing Research

admin — Tue, 24 Dec 2024 09:38:04 +0000

A study on wound healing, led by researchers at the University of Sheffield in the UK and COMSATS University in Pakistan, earlier this year made a remarkable discovery that can prove to be a potential new treatment for hereditary-patterned baldness-a disorder that has affected millions across the world.

The breakthrough centres on deoxyribose, a sugar that occurs naturally in the human body, forming part of DNA’s structure. In the first place, researchers were studying the sugar as related to the healing process in mice for skin wounds. To their surprise, they noticed accelerated fur growth around treated lesions compared with their untreated counterparts.

Motivated by this unforeseen discovery, the research group widened their exploration to seek the possibility of deoxyribose’s ability in promoting hair growth. While future studies are required for confirmation, the discovery still brings forth hopes for new therapeutic treatments in the fight against inherited baldness among both sexes. The findings of this discovery represent a long-awaited advance in addressing the most common cause of hair loss throughout the globe.

In a study published in June, it was shown that the deoxyribose sugar is as effective at regrowing hair as Minoxidil-an existing drug used to treat hair loss. However, the research offers a potential alternative approach to stimulating hair growth through a naturally occurring deoxyribose sugar.

Professor Sheila MacNeil, Emeritus Professor of Tissue Engineering at the University of Sheffield, said: “Male pattern baldness is such a common condition, affecting men all over the world, but at the moment there are only two FDA-licensed drugs to treat it. Our research suggests that the answer to treating hair loss might be as simple as using a naturally occurring deoxyribose sugar to boost the blood supply to the hair follicles to encourage hair growth.”

“The research we have done is very much in early stages, but the results are promising and warrant further investigation. This could offer another approach to treating this condition, which can affect men’s self-image and confidence.”

Professor (Associate) Muhammed Yar (TI) of IRCBM, COMSATS University Pakistan, said: “This pro-angiogenic deoxyribose sugar is naturally occurring, inexpensive, and stable, and we have shown it can be delivered from a variety of carrier gels or dressings. This makes it an attractive candidate to explore further for treatment of hair loss in men.”

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Nagaland University identifies natural compound with potential for diabetic wounds treatment

Scientists Discover Potential Baldness Treatment During Wound Healing Research